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Citrix vs VMware vs Azure Virtual Desktop

Choose based on your IT strategy: Citrix as an overlay for complex hybrid IT, Omnissa for on-prem VMware integration, or AVD for cloud-native Azure.

Carisa Stinger | October 1, 2025

Introduction

When evaluating virtual desktop infrastructure, you're comparing established, mature leaders with a modern, cloud-native platform. Citrix DaaS and Omnissa Horizon (formerly VMware's EUC division) have long powered VDI from the corporate data center, while Microsoft's Azure Virtual Desktop (AVD) was designed specifically for the era of cloud computing. 

This comparison is no longer just about features but about architectural philosophy—contrasting traditional, component-based infrastructure with an integrated, platform-based cloud service.

Disclaimer: Content referencing Citrix, Omnissa, and Microsoft products is based on public information from those company’s websites, current as of the last article update. Given the rapid pace of software updates (e.g., the Citrix Virtual Apps and Desktops 2507 LTSR) and recent industry consolidation, readers should always verify current features and version details directly with each vendor. For the latest product details and further inquiries, please consult the official company websites.

What are the core technologies behind Citrix, Omnissa Horizon, and Azure Virtual Desktop?

Understanding the core architecture of each platform is crucial because it directly impacts your team's management overhead and the solution's overall flexibility. The fundamental difference comes down to who manages the complex underlying infrastructure: your IT team or the cloud provider.

Citrix Virtual Apps and Desktops Omnissa Horizon (formerly VMware) Azure Virtual Desktop (AVD)
Control Plane Management Customer-Managed: IT team is responsible for deploying, configuring, and maintaining all back-end components. Customer-Managed: IT team is responsible for deploying and maintaining the Horizon infrastructure components. Microsoft-Managed: The entire control plane (broker, gateway, etc.) is delivered as a Platform-as-a-Service (PaaS).
Primary Environment Hybrid/Multi-Cloud: Designed to run on-premises in a data center or on any major public cloud (IaaS). On-Premises / Hybrid: Primarily designed for on-premises vSphere environments, with options for cloud deployment. Azure Cloud-Native: Runs exclusively in Microsoft Azure, with no on-premises component.
Core Components Component-Based: Requires multiple server roles like Delivery Controllers, StoreFront, and Gateway. Component-Based: Requires servers for Connection Server, Unified Access Gateway, and integration with vCenter. Integrated Service: Delivered as a single service; the customer manages session hosts, images, and applications.

(Note that architectural details may vary by version and deployment model.)

What is Citrix's core technology stack?

Citrix Virtual Apps and Desktops (CVAD) is a comprehensive solution built from multiple, distinct components that your IT team must install, configure, and maintain. To simplify this complexity, Citrix Cloud offers a SaaS-based management plane, allowing IT to manage both on-premises and cloud-based deployments from a single, unified console.

The front-end user experience is delivered through Citrix Workspace, a unified digital interface that provides access to all the virtual apps and desktops managed by the back-end components. This architecture requires you to manage a dedicated control plane, whether it's in your on-premises data center or on IaaS in the cloud.

  • HDX Protocol: A highly refined protocol optimized over decades for performance across varied and often challenging network conditions.
  • Independent Components: The architecture's strength is its flexibility, allowing you to swap out components, but this adds to its management complexity.

What is Omnissa Horizon's core technology stack?

Omnissa Horizon is a platform deeply integrated with the broader VMware ecosystem, particularly the vSphere hypervisor. This model relies on a single-vendor stack of components that your team is responsible for deploying and maintaining, making it a natural fit for organizations already invested in VMware infrastructure. However, the Horizon Cloud offering extends this capability, enabling deployment on multiple public cloud platforms, including AWS and Azure, to support hybrid and multi-cloud strategies.

  • Blast Extreme Protocol: This is Omnissa's modern, primary protocol, engineered for high-performance graphics and a seamless user experience, especially within stable corporate networks. The legacy PCoIP protocol is being phased out and will be removed from new Horizon releases by the end of 2025.
  • Tied to vSphere: Horizon provides the most value when run on its native hypervisor, creating a powerful but less flexible, single-vendor environment.

What is Microsoft Azure Virtual Desktop's (AVD) core technology stack?

Azure Virtual Desktop (AVD) operates on a completely different model as a Platform-as-a-Service (PaaS) offering. Microsoft manages the entire control plane—including the broker, gateway, and licensing—as part of your Azure subscription, freeing your IT team from the constant maintenance of VDI infrastructure.

  • Azure-Native PaaS: You don't build the VDI back-end; you consume it as a service, allowing your team to focus on managing images, applications, and user experience.
  • Windows 10/11 Enterprise Multi-Session: This cloud-era operating system is a key advantage, allowing multiple users on a single virtual machine to have a true Windows desktop experience, which significantly improves cost-efficiency.
  • Modern RDP: The Remote Desktop Protocol is continuously updated and optimized for the Azure cloud fabric, with deep native integrations for Microsoft 365 apps like Teams.

How do Citrix, Omnissa Horizon, and AVD compare on key features?

Choosing the right platform involves understanding the trade-offs between the granular control of traditional solutions and the streamlined integration of a modern cloud service. This comparison breaks down the key differences in platform support, user experience, and security models.

Citrix Virtual Apps and Desktops Omnissa Horizon (formerly VMware) Azure Virtual Desktop (AVD)
Platform Hypervisor-Agnostic: Offers maximum flexibility to run on diverse on-premises hypervisors (vSphere, Hyper-V, etc.) and in multi-cloud IaaS environments. VMware-Optimized: Primarily designed for and tightly integrated with the on-premises vSphere ecosystem, with cloud deployment options. Azure Cloud-Native: Exclusively a Platform-as-a-Service (PaaS) offering that runs only in Microsoft Azure, eliminating hypervisor management.
Protocol HDX Protocol: A mature and highly refined protocol renowned for its strong performance over challenging, low-bandwidth, and high-latency networks. Blast Extreme: A high-performance protocol optimized for high-fidelity graphics and a seamless experience on stable, high-bandwidth corporate networks. It is the sole protocol for modern Horizon deployments. Modern RDP: A modernized protocol that leverages the Azure global network for an optimized experience and features deep, native integration with Microsoft 365 services.
Security Model Component-Based Security: Relies on add-on components like Citrix Gateway to establish secure remote access, with granular policy controls managed by IT. Ecosystem-Integrated Security: Secures access via components like Unified Access Gateway and can integrate with VMware NSX for network micro-segmentation. Native Zero Trust Security: Employs a modern security model by default, integrating directly with Microsoft Entra ID Conditional Access, MFA, and the entire Azure security stack.
Management Style Granular Infrastructure Control: Requires specialized IT expertise to install, manage, and maintain the multiple back-end server components that form the control plane. Centralized Ecosystem Management: Managed through the Horizon Console and vCenter, requiring deep knowledge of the specific VMware infrastructure stack. Simplified Service Management: Microsoft manages the entire back-end, allowing IT to focus on user-facing elements like images, applications, and profiles, often via simplified tools like Nerdio.

How do these three handle platform and hypervisor support?

  • Citrix is hypervisor-agnostic, a trait that reflects its legacy as a flexible solution designed to overlay existing, diverse data center infrastructure. You can run it on vSphere, Hyper-V, or Nutanix AHV. This flexibility allows organizations to deploy Citrix on Azure, leveraging Microsoft's powerful cloud infrastructure while retaining the familiar Citrix management tools and user experience. This design philosophy ensures a high degree of compatibility with a wide range of legacy applications and diverse endpoint devices, which is a critical advantage for large enterprises with heterogeneous IT environments.
  • Omnissa Horizon is hypervisor-specific, designed to deliver a deeply integrated experience for organizations already committed to its traditional software-defined data center stack.
  • AVD is cloud-native and exclusively an Azure service. This approach eliminates hypervisor management entirely and allows you to leverage the full power of a single, integrated cloud platform.

How do their user experience and display protocols differ?

  • Citrix HDX is a mature and famously robust protocol, highly effective at being retrofitted for challenging, high-latency network conditions.
  • Omnissa's Blast Extreme is a high-performance protocol designed for the stability and high bandwidth of corporate LANs.
  • Microsoft RDP is a modern protocol that leverages the global Azure network backbone for an optimized user experience and features deep, native integration with essential business tools like Microsoft Teams.

What are the security models of each platform?

  • Citrix & Omnissa Horizon rely on well-established security principles that often require add-on components like dedicated gateways (Citrix Gateway, Omnissa Unified Access Gateway) or separate network virtualization platforms.
  • AVD employs a modern, Zero Trust security model by default. It natively integrates with the entire Azure security fabric, including Microsoft Defender for Cloud, Microsoft Sentinel, and Entra ID for powerful Conditional Access policies.

What are the main use cases for Citrix, Omnissa Horizon, and AVD?

The best choice for your organization depends entirely on your business goals and where you are on your IT modernization journey. This spectrum illustrates how each platform aligns with different strategic priorities, from maximizing on-premises investments to embracing a cloud-native future:

When are traditional platforms like Citrix or Omnissa Horizon a fit?

These platforms excel when your strategy is centered on your existing data center. Consider them if you need to:

  • Extract maximum value from current on-premises infrastructure investments.
  • Support complex hybrid environments that bridge legacy applications to the cloud.
  • Maintain granular, component-level control over your entire VDI infrastructure stack.

When is a modern platform like AVD a fit?

AVD is designed for organizations that are strategically aligning with the cloud. It's the ideal choice when your goals are to:

  • Standardize on the Microsoft ecosystem, creating a seamless experience across Azure and Microsoft 365.
  • Reduce IT operational overhead by shifting from managing infrastructure to consuming a service.
  • Achieve rapid scaling, deployment agility, and a simplified security model based on integrated cloud services.

Know the TCO

This step-by-step wizard tool gives you the total cost of ownership for AVD in your organization.

How can you modernize your VDI strategy and simplify management on Azure?

Adopting a modern VDI platform like AVD is a strategic move to reduce infrastructure debt and increase agility. However, managing any large-scale virtual desktop environment in the cloud comes with its own set of operational challenges.

What complexities exist when adopting a modern VDI platform?

While AVD and Windows 365 remove the need to manage the control plane, enterprise IT teams are still responsible for key operational tasks. At scale, challenges around image management, application deployment, host pool automation, and especially cost control can become significant hurdles. Without the right tools, the promised efficiency of the cloud can be difficult to achieve.

How does Nerdio Manager for Enterprise accelerate VDI modernization?

Nerdio provides the tools to bridge the gap between traditional VDI management and modern cloud-native desktops, making the transition seamless and cost-effective.

  • What is Nerdio's role? Nerdio Manager for Enterprise is a deployment, management, and optimization platform built exclusively to run on top of Azure Virtual Desktop (AVD) and Windows 365. It is not a VDI broker itself but rather an automation and management layer that unlocks the full potential of Microsoft's native platforms.
  • How does Nerdio bridge the gap from legacy VDI? For organizations moving from traditional platforms like Citrix and VMware, Nerdio provides a clear migration path and a powerful, intuitive management interface. It adds the enterprise-grade features that IT teams are accustomed to, making the switch to a modern Microsoft VDI strategy straightforward.
  • How does Nerdio enhance modern platform management? Nerdio adds a necessary layer of enterprise-grade control and cost optimization on top of the native AVD and Windows 365 platforms. Its advanced, event-driven autoscaling can dramatically reduce Azure compute and storage costs, often by more than 50%. Furthermore, it automates complex tasks like image creation and host pool management, making Microsoft's VDI platforms easier to run at scale than even the most mature legacy solutions.

See this demo to learn how you can optimize processes, improve security, increase reliability, and save up to 70% on Microsoft Azure costs.

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About the author

Photo of Carisa Stinger

Carisa Stinger

Head of Product Marketing

Carisa Stringer is the Head of Product Marketing at Nerdio, where she leads the strategy and execution of go-to-market plans for the company’s enterprise and managed service provider solutions. She joined Nerdio in 2025, bringing 20+ years of experience in end user computing, desktops-as-a-service, and Microsoft technologies. Prior to her current role, Carisa held key product marketing positions at Citrix and Anthology, where she contributed to innovative go-to-market initiatives. Her career reflects a strong track record in driving growth and adoption in the enterprise technology sector. Carisa holds a Bachelor of Science in Industrial Engineering from the Georgia Institute of Technology.

*As of 2024, VMware's End-User Computing (EUC) division, which includes the Horizon product line, has been spun off and is now an independent company named Omnissa.

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